• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a nutritional adjuvant comprising baascarine and / or baaleine, and a food comprising such an adjuvant intended to improve production performance by animals in a situation of discomfort.
    公开号:FR3017778A1
    申请号:FR1451501
    申请日:2014-02-25
    公开日:2015-08-28
    发明作者:Fabrice Robert
    申请人:DELTAVIT；
    IPC主号:
    专利说明:

    [0001] The field of the invention The technical field of the present invention is that of the food additives and the feeds for farmed animals. More particularly, the present invention relates to plant extracts for maintaining and increasing productivity in annoying livestock. Livestock discomfort situations are correlated with physiological and behavioral changes that sensitize farm animals to pathologies. These situations have an even more negative impact on their well-being. One of the consequences is a drop in the productivity of these weakened animals, be it milk production, eggs, meat or any other product. The phases of discomfort are also characterized by production below the genetic potential of animals. Performance enhancers have been used and incorporated into foods, including antibiotics that were intended, in ruminant animals for example, to direct ruminal fermentation by selecting only beneficial bacteria. These antibiotic enhancers also stimulate livestock production by reducing inflammation (Niewold, 2007). Indeed, inflammatory phenomena reduce the production of meat, milk and eggs, (Klasing et al, 1997, Trevisi et al, 2010) during events generating discomfort situations such as farrowing, weaning, thermal or environmental changes, unsuitable conditions ... Moreover, the use of antibiotics by breeders follows the occurrence of adverse events.
    [0002] These antibiotic enhancers represent potential public health risks through the development of resistance in bacteria and rejection by consumers. Many plant extracts show anti-inflammatory and antioxidant effects (Kim et al, 2004, RiceEvans et al, 1996). They represent natural nutritional alternatives capable of acting simultaneously on the welfare of farm animals and the maintenance of their production regardless of the breeding conditions. These plant extracts can be integrated into animal feeds with nutritional supplements or their drinking water. PRIOR ART The patent application CN102805271 discloses an anti-stress, anti-diarrheal, pro-growth food additive for weaned pork derived from Chinese herbal medicine. This additive is obtained by mixing fine crushed Astragalus mongholicus, Scutellaria baicalensis, malt, licorice, dangshen, Poria cocos and Atractylode rhizome. According to Chinese herbal medicine, the additive according to the present invention can increase the growth performance of weaned pigs, the additive has anti-diarrheal effects; the development of the gastrointestinal tract of weaned pigs can be improved; the activity of digestive enzymes of the gastrointestinal tract can be improved to support the development of the digestive enzymatic system of pigs; the micro-ecological environment of the digestive tract of pigs can be regulated and stabilized to accelerate the growth of pigs; the antioxidant function of the organism of weaned pigs can be improved to enhance the compensatory capacities of the pigs organism against environmental irradiation; the shape of the intestinal mucosa is improved to prevent sagging intestinal villi and strengthen the restoration of the intestinal tract; and the immune function of the intestinal mucosa of weaned pigs can be regulated. Patent application CN103315145 discloses a weaner pig feed comprising an additive composed of Chinese yam, purple perilla, Scutellaria baicalensis, dyer's safflower, Houttuynia cordata, Leonurus, Radix dichroa and licorice. Piglet feed can provide the basic nutrients once weaned piglets. At the same time, by the addition of the additive, the growth and immunity of the piglets can be increased. The patent application CN101816382 discloses a food additive and its use in disease resistance and to increase oviposition. This additive comprises a mixture of plant extracts known from traditional Chinese medicine including an extract of Scutellaria baicalensis. Scutellaria baicalensis is a plant of Asian origin. Its extracts include two main active ingredients of the family of flavones, Baçcaline and Baçalein. These show anti-inflammatory (Chou et al, 2003, Hsieh et al, 2007) and anti-viral activities.
    [0003] Non-Patent Literature Cited: - Ballou, MA, Immune responses of Holstein and Jersey calves during the preweaning and immediate postweaned periods when dieters of milk replacer, J. Dairy Sci, 5 2012; 95 (12): 7319-30 - Cabbage , Tc, Chang, L.-P., Li, C.-Y., Wong, C.-S., & Yang, S.-P. (2003). The Antiinflammatory and Analgesic Effects of Baicalin in Carrageenan-Evoked Thermal Hyperalgesia. Anesthesia & Analgesia, 1724-1729. 10 doi: 10.1213 / 01.ANE.0000087066.71572.3E - Farney, JK, Mamedova, LK, Coetzee, JF, Minton, JE, Hollis, LC, Bradford, BJ, Sodium salicylate treatment in early lactation increases whole-lactation milk and milk Fat yield in mature dairy cows, J. Dairy Sci, 2013; 96 (12): 7709-18. 15 - Hsieh, C.-J., Hall, K., Ha, T., Li, C., Krishnaswamy, G. ., & Chi, DS (2007). Baicalein inhibits IL-1beta and TNF-alphainduced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. Clinical and Molecular Allergy CMA, 5, 5. doi: 10.1186 / 1476-7961-5-5 - Kim, H.P., Son, K.H., Chang, H.W., & Kang, S.S. (2004). Critical Review Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms. Journal of Pharmacological Sciences, 245, 229 - 245. Klasing, K.C., Korver, D.R., & Korver, I. (1997). Leukocytic Cytokines Regulate Growth Rate and Composition Following Activation of the Immune System Leukocytic Cytokines Regulate Growth Rate and Composition Following Activation of the Immune System 1. Journal of Animal Science, 75, 58-67. - Niewold, T. a. (2007). The nonantibiotic anti-inflammatory effect of antimicrobial growth promoters, the real mode of action A hypothesis. Poultry Science, 86 (4), 605-9. - Rice-Evans, C.A., Miller, N.J., & Paganga, G. (1996). Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free radical biology and medicine, 20 (7), 933956. Sordillo, LM, Raphael, W., Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders, Vet Clin North Am Food Anim Pract, 2013; 29 ( 2): Trevisi, E., Zecconi, A., Bertoni, G. and Piccinini, R. (2010). Blood and milk immune and inflammatory profiles in dairy farming. The Journal of dairy research, 77 (3), 310-7. doi: 10.1017 / S0022029910000178 Disadvantages of the Prior Art The solutions of the prior art are complex combinations of different plant extracts requiring fine dosages. These combinations and their dosages are intended for a very specific species at a given stage of development, for example just weaned piglets. The solutions of the prior art are not immediately applicable to any kind of rent. In addition, these solutions consist of crude extracts of plants. But the extracts are variable in their composition in active principles and we can not ensure in these conditions a consistency in the effects. The variability according to the different preparations of extracts and mixture of extracts is very important and raises a concern for reproducibility and reliability. However, it is necessary, in order to ensure consistency of effect, to have identified the extract responsible for the biological activity sought, to be able to assay one or more active ingredients characterizing the extract and the associated effects and to ensure constant supply to the animals, corresponding to the active dose.
    [0004] Solution Provided by the Invention The present invention proposes in its most general acceptance to overcome the disadvantages of the prior art by providing a nutritional adjuvant for the improvement of production performance by animals in a situation of discomfort, comprising Baçcaline and / or Baaleine. It is understood that the invention may also include derivatives of bacaline and baaleine. Advantageously, the baocalin and / or Baaceine are provided by an extract of Scutellaria baicalensis. Surprisingly, the applicant has observed that extracts, in particular of root, of Scutellaria baicalensis incorporated into the feed of livestock increased their production and normalized the disorders caused by the situations of discomfort without resorting to any form. medication, including antibiotics. In particular, the root extract of Scutellaria baicalensis comprises, as active ingredients, bacaline and baaleine. These molecules are traceable throughout the manufacture of adjuvants and foods according to the invention. According to another embodiment, baïcaline and / or baaleine are obtained by chemical synthesis. It will be understood that baascarine and / or baaleine may be obtained by extraction or by chemical synthesis according to the methods known to those skilled in the art.
    [0005] Preferably, the adjuvant comprises baalkaline and baaleine but the adjuvant may comprise only one of the two molecules. Preferentially, the baçcaline and / or the baçalein are provided by a root extract of Scutellaria baicalensis. The extract of Scutellaria baicalensis is preferably an extract of the root of the plant, in powder form and obtained by hydro-alcoholic extraction. It is understood that the extract of Scutellaria baicalensis may be in dry or liquid form. The extract comprises a known amount by weight of active ingredient consisting of baascarine and / or baaleine, typically between 10 and 50% by weight of bacaline. This nutritional adjuvant can be used in all livestock, such as not limited to, poultry, rabbits, ruminants, sheep, cattle, goats, horses, fish, crustaceans, pigs, with the exception of just weaned piglets. Livestock are animals kept for the production of foodstuffs.
    [0006] The adjuvant according to the invention is well tolerated by all livestock and has good safety in these species. The nutritional adjuvant comprises baadaline and / or baaleine diluted on a support, such that baascarine and / or baaceine are distributed to the animal at a dose of between 0.1 and 20 mg per kg of body weight and per day. The adjuvant is obtained by diluting the dry extract of Scutellaria baicalensis on a support, said support being able to be liquid if its destination is a drink or said support can be solid if its destination is a solid feed product. If the final destination is to be mixed with the drinking water of livestock, then the dilution medium may be water or a mixture of water with added minerals and / or trace elements or any other additive or solvent known to those skilled in the art as being conventionally incorporated into the drinking water. If the final destination is a solid food, the carrier may comprise a cereal or a mixture of cereals such as wheat, barley, oats or any other raw material or additive known to those skilled in the art. By discomfort is meant all environmental conditions that have a negative impact on the production of livestock. These may include stimuli affecting the physiology and behavior of animals, including, but not limited to, variations in temperature, humidity, luminosity, proximity to other animals, calving, weaning, transportation, contact with humans, changes in the medium ... The nutritional adjuvant according to the invention stimulates the conversion of food and / or the food consumption of animals in a situation of discomfort. By dietary conversion is meant the ratio between the dry weight of the food distributed and the gain in production obtained. It is understood that the nutritional adjuvant according to the invention increases the productivity of livestock by increasing the feed conversion, that is to say that given equal weight of food, the animal has a better growth and better productivity. By food consumption is meant the daily amount of food consumed by each animal. It is understood that the nutritional adjuvant according to the invention stimulates the appetite of animals and therefore their production. Advantageously, the nutritional adjuvant is applied to the stimulation of lactation in animals in a state of discomfort, to the stimulation of the production of eggs in animals in a state of discomfort, to the stimulation of the growth of animals in situation of discomfort, to the stimulation of the resistance to the pathologies of the animals in situation of discomfort.
    [0007] The nutritional adjuvant according to the invention does not include antibiotics. The invention also comprises an animal feed comprising a nutritional adjuvant intended to improve production performance by animals in a state of discomfort, comprising an extract of Scutellaria baicalensis, with a known concentration of flavonoid-type active principles, or synthetic flavonoids, said flavonoids being preferentially bacaline and / or baaleine and their derivatives. The food can be in liquid form, slurry, paste, granules, powders or any other solid form. It comprises the adjuvant, on a support, comprising flavonoids of the baïcaline and / or bayaleine type, preferably an extract of Scutellaria baicalensis, making it possible to provide the animal with between 0.1 and 20 mg / kg of live weight per day of active ingredient Baçcaline / Baçalein. The food comprising an adjuvant according to the invention can be used for improving the production performance by animals in a state of discomfort, for the stimulation of lactation in animals in a state of discomfort, for the stimulation of the production of eggs in animals in a state of discomfort, for the stimulation of the growth of animals in a situation of discomfort or for the stimulation of resistance to the pathologies of animals in a situation of discomfort.
    [0008] Description To demonstrate the effectiveness of the adjuvant according to the invention, in vivo experimental assays were performed in different species of livestock subjected to stress. Figure 1 shows the results of the evolution of the average daily milk production in the cow receiving a food according to the invention. It has been shown that calving discomfort situations are likely to alter health status and lactation (Ballou 2012, Farney et al., 2013, Sordillo & Raphael 2013). Test 1: Study of the effect of administration of a feed comprising the adjuvant comprising an extract of Scutellaria baicalensis on a solid support on milk production by dairy cows under stress Protocol: was carried out on a herd of one hundred dairy cows of Prim'Holstein breed. 24 dairy cows calving in the same period were divided into two groups of twelve according to calving date, lactation rank, amount of milk produced, fat content, protein level at 305 days of previous lactation for multiparous, milk index for primiparous. The corn silage ration is identical for both batches except for the addition of an adjuvant according to the invention including 10% of an extract of Scutellaria baicalensis on a calcium carbonate support. This adjuvant is incorporated at 0.5% in the production feed (17% crude protein, 1 UFL) distributed at a rate of 2 kg per cow per day in the test batch. Each cow receives 1 gram per day of Scutellaria baïcalensis extract, ie 333 mg of Baçcaline or 0.5 mg / kg body weight.
    [0009] Results on milk production: Milk production is significantly improved over the two months of monitoring. The effect of Scutellaria baïcalensis extract on lactation occurs after the first month (phase 2 in Figure 1). Figure 1 shows the improvement in average daily milk yield in cows receiving a feed supplemented with Scutellaria baicalensis extract according to the invention compared to cows in the control group. Table 1 summarizes milk production averages of cows by diet. Dairy production was significantly increased in cows in the group receiving a diet supplemented with Scutellaria baïcalensis. Lot Total Period 1 Period 2 Scutellaria 44 42.8 45.9 Control 42.5 41.7 42.9 P <0.05 ns <0.05 Table 1. Dairy production in kg / cow / day (ns: not significant) Trial 2: Study of the effect of a lactating food comprising an extract of Scutellaria baïcalensis on the lactation of sows. Unlike dairy cows whose milk production is directly measurable, the measurement of milk production of sows is indirect and is measured by the weight gain of piglets suckled by their mother (GMQ Average Daily Gain in grams).
    [0010] Protocol: 55 sows are divided into two groups. Foods whose characteristics are shown in Table 2 are distributed throughout lactation of the sows. The adjuvant Scutellaria baïcalensis is composed of an extract of Scutellaria baïcalensis incorporated at 1.5% on a support. The test food contains 150 mg of Scutellaria baïcalensis extract per kg or 50 mg per kg of Bacaline food. These foods are distributed to sows three days before 10 farrowing until piglet weaning (21 days after farrowing). 632 piglets are included in the test. Foods lactation Control Trial SOWS WHEAT (MJ / kg) 9.7 9.7 Fatty matter (%) 5.3 5.3 Raw protein (%) 16.5 16.5 Crude Cellulose (%) 6.3 6.3 Digestible Lysine (%) 0.9 0.9 Digestible Phosphorus (%) 0.32 0.32 Electrolytic scale (mEq / kg) 175 175 Ca / P digested 2.8 2.8 Wheat (%) * 20.0 19.0 Barley (%) 17.6 17.6 Maize (%) 8.6 8.6 Milurex (%) 10.0 10.0 Pea (%) 6.0 6.0 Soybean (%) 3.0 3.0 Soybean meal (%) 7.5 7.5 Oilseed rape (%) 4.2 4.2 Sunflower meal (%) 8.0 8.0 Beet pulp (%) 6.0 6.0 Rapeseed oil (%) 2.3 2.3 Adjuvant Scutellaria - 1.0 Baïcalensis * (*) 1% of wheat is brought by the support of the adjuvant. Table 2. Characteristics of Foods Distributed to Sows 15 Results of Trial 2: The TEST food differs from the control diet only in the incorporation of the adjuvant according to the invention comprising an extract of Scutellaria baicalensis.
    [0011] The piglets of the sows of both lots have weights equivalent to birth. Table 3 below presents the effects of an extract of Scutellaria baïcalensis on the milk production of sows evaluated by the growth of suckling piglets (GMQ: average daily gain of suckling piglets). Weaning weight and ADG were significantly higher in piglets fed a sow that consumed a diet supplemented with Scutellaria baicalensis. Average weight of weight at GMQ (g / d) piglets at weaning (kg) (kg) Control 1.33 5.68 235 Scutellaria baïcalensis 1.32 6.04 264 Comparison of average - significance ns <0.001 <0.001 Table 3. Average weight of piglets according to Feeding the sow Piglet weighings reveal a higher growth of piglets whose mothers consume a food containing an extract of Scutelaria baïcalensis. This demonstrates that dairy production of sows is stimulated by Scutellaria baïcalensis extract. Test 3: study of the effect of the administration of a food comprising the adjuvant to the extract of Scutellaria baicalensis on a solid support on the food consumption of 25 laying hens subjected to thermal discomfort Protocol: 72 Laying hens Isabrown 30 weeks old at the beginning of the test were divided into three groups of twelve cages of two hens. The test is conducted up to 38 weeks. Group 1 receives the control feed whose characteristics are shown in Table 4. Group 2, otherwise known as the OTC group, receives the control feed supplemented with an antibiotic, 400 ppm oxytetracycline. Group 3, otherwise known as SCU group, receives the control diet supplemented with a Scutellaria baicalensis root extract providing 6 mg / kg of BaCalin feed. Name raw materials% BLE 30.00 BUT 36.62 Oilcake SOJA 21.40 SOYBEAN OIL 0.80 Sodium BICARBONATE 0.12 BICALCIUM PHOSPHATE 1.26 CARBONATE 7.54 SALT 0.28 METHIONINE 15 / BLE 85 0.98 Supplement mineral and vitamin 1 Table 4: Formula of the staple food distributed After three weeks of distribution of the experimental feed, the layers are subjected to a temperature variation. The temperature of the environment is increased from 22 ° C (thermal comfort temperature) to 35 ° C for 5 days. Feed consumption, number of eggs laid and mean weight of eggs are recorded weekly and daily during the week of high temperature and the following week. The test was cut into three phases: thermal pre-increase phase, thermal discomfort phase and high post-temperature phase. Results: The consumptions during the pre-thermal increase phase are identical between the different groups. During the thermal discomfort phase, the daily consumptions per hen are respectively 50.9 g, 53.5 g and 59.7 g for the control, OTC and UCS groups, the UCS group showing a significantly higher consumption (p <0.05). Group 3, SCU laying hens increased their feed consumption by 17% during the thermal discomfort phase. The laying rate over the two weeks integrating the thermal discomfort phase and the following week are respectively 85.2, 88.5 and 87.2% for the hens receiving the control food, the food supplemented with the antibiotic and the extract. of Scutellaria baïcalensis. Test 4: Study of the effect of the administration of a food comprising the adjuvant consisting of an extract of Scutellaria baicalensis on a solid support on the growth of chickens subjected to a high temperature 80 yellow Ross PM3 chickens are distributed in two groups of 20 cages of two chickens. Group 1 is the control group. Group 1 chickens are fed a control food whose composition is recapitulated in Table 5. Group 2 receives the control food supplemented with an adjuvant according to the invention comprising an extract of Scutellaria baicalensis at 6 mg / kg of baïcaline food. The extract of Scutellaria baïcalensis is provided by an adjuvant containing 0.5% of the extract and 99.5% wheat in substitution of wheat in the formula. TITLE 0/0 WHEAT 30.00 BUT 34.25 SOYBEANS 4.20 Cake SOYBEANS 25.70 SOYBEAN OIL 1.50 SODIUM BICARBONATE 0.21 BICALCIUM PHOSPHATE 1.43 CARBONATE 0.62 SALT 0.20 METHIONINE 15 / BLE 85 1.07 L-LYSINE 20 / BLE 75 0.42 PREMIX Vitamin Oligo 0.40 Table 5. Composition of the staple food From the twenty-fifth to the thirtieth day, chickens are subject to an artificial increase in environmental temperature of 22 ° C to 36 ° C to induce discomfort. The chickens are weighed before and after the thermal discomfort phase and their food consumption is measured (day 24 and day 30). The test is prolonged until 30 days. Results: Table 6 summarizes the results obtained in the two groups of chickens during the thermal discomfort phase (day 24 to day 30). Initial weight Final weight after thermal comfort phase GMQ CMJ (g / d) ICT before (g) (g / d) thermal discomfort phase (g) Control 1290 1786 82.6 152.2 1.94 Baïcaline 1257 1837 96.6 168.5 1.74 Comparison of Mean - Significance ns ns 0.002 0.001 0.11 GMQ, average daily gain - CMJ, average daily consumption - ICT, technical consumption index Table 6. Weight of chickens according to their diet Before the period of discomfort related to excessive temperature in buildings the growth of the birds receiving the two foods is equivalent (weight at 24 days not different between batches). The mean daily dietary intake (SCM) of the group receiving the feed comprising an extract of Scutellaria baicalensis was greater by 10.7% and the mean daily gain (ADG) was greater by 17% compared to the control group. during the thermal discomfort phase. This results in a better growth of the treated chickens compared to the chickens of the control group. Test 5: Study of the effect of the administration of a food comprising the adjuvant to the extract of Scutellaria baicalensis on a solid support on the improvement of the state of health and on the resistance to pathologies of piglets Discomfort Piglets are 42 days old at the start of the test. Three groups are constituted: a control group, a group receiving the same food supplemented with 100 ppm of an antibiotic (tylosin) and finally the last group receives a food supplemented with 100 ppm of an extract of Scutellaria baicalensis, ie 30 ppm of BaCalin per kg of food. The pathologies are recorded as well as the curative treatments performed in each group. The results are shown in Table 7.
    [0012] P (Chi2) Antibiotic Control Tylosin Scutellaria Extract (100 ppm in baïcalensis feed) (100ppm in feed) Pigs tested 19 25 20 Number of deaths 0 0 0 Withdrawn during trial 0 1 0 Mortality + elimination (%) 0.0 4.0 0 Number of treatments 15 14 5% treatments 78.9 56.0 25 Aqueous diarrhea 7 4 3 Skinny 0 2 0 Lameness ooo Cough 8 7 2 Nervous symptoms 0 1 0 Number Treated pigs 13 13 5% Treated pigs 68.4 52 25% Untreated pigs 31.6 48 75 Pigs treated by cause Aqueous diarrhea 7 4 3 Lean 0 2 0 Lameness 0 0 0 Cough 8 7 2 Nervous symptoms 0 1 0 <0.05 < 0.05 Table 7. Pathological episodes in weaned piglets according to their diet. Significantly fewer patients in the group receiving an adjuvant comprising an extract of Scutellaria baïcalensis according to the invention are present and the number of curative treatments is also reduced. The typology of the symptoms recorded shows a general unspecific improvement in the state of health because digestive problems such as respiratory problems are improved.
    权利要求:
    Claims (4)
    [0001]
    CLAIMS1 - Nutritional adjunct intended to improve the production performance of animals in a situation of discomfort, comprising betaline and / or baaleine.
    [0002]
    2 - Nutritional adjuvant according to the main claim characterized in that the bacaline and / or baaleine are provided by an extract of Scutellaria baicalensis. 10
    [0003]
    3 - nutritional adjuvant according to the main claim characterized in that the bacaline and / or baaleine are obtained by chemical synthesis.
    [0004]
    4 - Nutritional adjuvant according to any one of the preceding claims, characterized in that it comprises baalkaline diluted on a support, so that the bacaline is distributed to the animal at a dose of between 0.1 and 20. mg per kg body weight per day. Nutritional adjuvant according to any one of the preceding claims, characterized in that it stimulates the feed conversion and / or the food consumption of animals in a situation of discomfort. 6 - nutritional adjuvant according to any one of the preceding claims, characterized in that it does not include antibiotics. 7 - Animal feed comprising an adjuvant according to any one of the preceding claims. 8 - Use of a food comprising an adjuvant according to any one of the preceding claims for the improvement of production performance by animals in a state of discomfort.9 - Use of a food comprising an adjuvant in accordance with the present invention one of claims 1 to 7 for the stimulation of lactation in animals in a situation of discomfort. 10 - Use of a food comprising an adjuvant according to one of claims 1 to 7 for stimulating the production of eggs in animals in discomfort. 11 - Use of a food comprising an adjuvant according to one of claims 1 to 7 for stimulating the growth of animals in discomfort. 12 - Use of a food comprising an adjuvant according to one of claims 1 to 7 for the stimulation of resistance to pathologies of animals in the situation of discomfort.
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    CN107375753A|2017-08-14|2017-11-24|宜宾五尺道集团有限公司|A kind of autumn and winter market pig health care preparation and application|
    FR3077707A1|2018-02-15|2019-08-16|Mixscience|ANTI-STRESS COMPOSITION|
    CN108850605A|2018-07-19|2018-11-23|日照普惠动物营养科技有限公司|A kind of feed addictive reducing diarrhea of weaned piglets|
    法律状态:
    2016-01-21| PLFP| Fee payment|Year of fee payment: 3 |
    2017-01-24| PLFP| Fee payment|Year of fee payment: 4 |
    2018-01-23| PLFP| Fee payment|Year of fee payment: 5 |
    2020-01-22| PLFP| Fee payment|Year of fee payment: 7 |
    2021-01-20| PLFP| Fee payment|Year of fee payment: 8 |
    2022-01-19| PLFP| Fee payment|Year of fee payment: 9 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1451501A|FR3017778B1|2014-02-25|2014-02-25|ADJUVANT COMPRISING BAICALIN PARTICULARLY FROM AN EXTRACT FROM SCUTELLARIA BAICALENSIS AND ANIMAL FEED COMPRISING SUCH AN ADJUVANT|FR1451501A| FR3017778B1|2014-02-25|2014-02-25|ADJUVANT COMPRISING BAICALIN PARTICULARLY FROM AN EXTRACT FROM SCUTELLARIA BAICALENSIS AND ANIMAL FEED COMPRISING SUCH AN ADJUVANT|
    CA2939968A| CA2939968A1|2014-02-25|2015-02-25|Adjuvant containing baicalin, particularly from a scutellaria baicalensis extract, and animal feed containing such an adjuvant|
    HUE15715784A| HUE045279T2|2014-02-25|2015-02-25|Use of an extract of scutellaria baicalensis comprising baicaline during the parturition period for stimulating lactation in livestock animals.|
    MX2016011113A| MX371159B|2014-02-25|2015-02-25|Adjuvant containing baicalin, particularly from a scutellaria baicalensis extract, and animal feed containing such an adjuvant.|
    PCT/FR2015/050450| WO2015128580A1|2014-02-25|2015-02-25|Adjuvant containing baicalin, particularly from a scutellaria baicalensis extract, and animal feed containing such an adjuvant|
    US14/910,707| US20160354398A1|2014-02-25|2015-02-25|Adjuvant containing baicalin, particularly from a scutellaria baicalensis extract, and animal feed containing such an adjuvant|
    RU2016137635A| RU2694192C2|2014-02-25|2015-02-25|Additive containing baicalin, in particular from scutellaria baicalensis extract, and animal fodder containing such additive|
    EP15715784.3A| EP3133935B1|2014-02-25|2015-02-25|Use of an extract of scutellaria baicalensiscomprising baicaline during the parturition period for stimulating lactation in livestock animals.|
    PL15715784T| PL3133935T3|2014-02-25|2015-02-25|Use of an extract of scutellaria baicalensis comprising baicaline during the parturition period for stimulating lactation in livestock animals.|
    CN201580009275.4A| CN106102474A|2014-02-25|2015-02-25|Containing scutelloside, especially from the adjuvant of scutelloside of Baical Skullcap root P.E and the animal feed containing this adjuvant|
    ES15715784T| ES2732480T3|2014-02-25|2015-02-25|Use of an extract of Scutellaria baicalensis comprising baicalin during the period of delivery to stimulate lactation in farm animals|
    PT15715784T| PT3133935T|2014-02-25|2015-02-25|Use of an extract of scutellaria baicalensis comprising baicaline during the parturition period for stimulating lactation in livestock animals.|
    BR112016019711A| BR112016019711A2|2014-02-25|2015-02-25|baicalin-containing adjuvant, particularly from a scutellaria baicalensis extract and animal feed containing such adjuvant|
    MA39303A| MA39303A1|2014-02-25|2015-02-25|Adjuvant comprising baïcaline in particular derived from an extract of scutellaria baicalensis and animal feed comprising such an adjuvant|
    DK15715784.3T| DK3133935T3|2014-02-25|2015-02-25|Use of an extract of Scutellaria baicalensis, comprising baicalin, during the breeding period to stimulate the milk formation in breeding animals|
    US16/553,218| US11077127B2|2014-02-25|2019-08-28|Adjuvant containing baicalin, particularly from a Scutellaria baicalensis extract, and animal feed containing such an adjuvant|
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